期刊论文详细信息
Iranian Journal of Basic Medical Sciences
Selenium supplementation in the form of selenium nanoparticles and selenite sodium improves mature male mice reproductive performances
Ali Shalizar-Jalali1  Golamreza Najafi1  Alireza Nourian1  Mobin Koohestani1  Siamak Asri-Rezaei2  Ali Nazarizadeh2  Ali Karimi3 
[1] Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran;Department of Clinical Pathology and Internal Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran;Ph.D. Student of Histology, Faculty of Veterinary Medicine, Urmia University, Urmia, West Azerbaijan, Iran;
关键词: Mice;    Nanoparticle;    Selenium;    Spermatogenesis;    Testis;   
DOI  :  10.22038/ijbms.2018.26023.6397
来源: DOAJ
【 摘 要 】

Objective(s): The current study was conducted to examine the possible protective and retentive effects of one-week intra-peritoneal (IP) administration of selenium nanoparticles (Se-NPs), compared to its bulk counterpart, selenite sodium (Ss), after one complete cycle of spermatogenesis in mature male mice. Materials and Methods: Thirty adult male mice were divided into 3 groups. Control group was administrated phosphate-buffered saline (IP) and the other groups received Ss (0.50 mg kg-1) and Se-NPs (0.50 mg kg-1) for seven successive days. Then, the animals were monitored for 28 days and finally sacrificed and tissue and blood samples were taken. Histopathological features, sperm quality, in vitro fertilization (IVF) capability and selenium (Se) content in testicular tissue were analyzed. Antioxidant enzyme activities including catalase, glutathione peroxidase, and superoxide dismutase as well as total antioxidant capacity and malondialdehyde levels were assessed in blood and the tissue samples. Results: Remarkable differences were found in sperm characteristics, histopathological features and oxidative stress biomarkers between control and treatment groups. Moreover, IVF evaluation and tissue Se concentration examination weren’t similar for Se-NPs and Ss. Conclusion: Conclusively, Se-treated groups had more antioxidant capacity than the control group, but sperm quality and histopathological features revealed that Se-NPs might possess more antioxidative and retentive potential compared to Ss in one spermatogenesis cycle.

【 授权许可】

Unknown   

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