Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Frontiers in Cell and Developmental Biology

Jing Hou¹  Yurui Jiao¹  Kaixuan Chen¹  Chen He¹  Ling Liu¹  Wenzhen He¹  Mi Yang¹  Mei Huang¹  Changjun Li²  Xianghang Luo² 

[1] Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China;Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China;

关键词: macrophages;    intracellular communication;    macrophage-derived exosome;    bone remodeling;    bone diseases;   

DOI  :  10.3389/fcell.2020.598263

来源: DOAJ

【 摘 要 】

The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.

【 授权许可】

Unknown