Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

eLife

Jean-François Nankoo¹  Shakthi Sanjana Seerala²  Robert Chen³  Kai-Hsiang Stanley Chen³  Yanqiu Wang³  Anton Fomenko³  James Saravanamuttu³  Mazen El-Baba³  Xue Xia³  Kullervo Hynynen⁴  Andres M Lozano⁴ 

[1] Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan;Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada;Krembil Research Institute, University Health Network, Toronto, Canada;Sunnybrook Research Institute, Toronto, Canada;

关键词: focused ultrasound;    neuromodulation;    transcranial ultrasound;    transcranial magnetic stimulation;    noninvasive brain stimulation;    brain stimulation;   

DOI  :  10.7554/eLife.54497

来源: DOAJ

【 摘 要 】

Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural activity. We investigated how different fundamental sonication parameters influence the effects of TUS on the motor cortex (M1) of 16 healthy subjects by probing cortico-cortical excitability and behavior. A low-intensity 500 kHz TUS transducer was coupled to a transcranial magnetic stimulation (TMS) coil. TMS was delivered 10 ms before the end of TUS to the left M1 hotspot of the first dorsal interosseous muscle. Varying acoustic parameters (pulse repetition frequency, duty cycle, and sonication duration) on motor-evoked potential amplitude were examined. Paired-pulse measures of cortical inhibition and facilitation, and performance on a visuomotor task was also assessed. TUS safely suppressed TMS-elicited motor cortical activity, with longer sonication durations and shorter duty cycles when delivered in a blocked paradigm. TUS increased GABAA-mediated short-interval intracortical inhibition and decreased reaction time on visuomotor task but not when controlled with TUS at near-somatosensory threshold intensity.

【 授权许可】

Unknown