Human Umbilical Cord Blood Cell Transplantation in Neuroregenerative Strategies

Frontiers in Pharmacology

Yana O. Mukhamedshina¹  Albert A. Rizvanov²  Luisa R. Galieva²  Svetlana S. Arkhipova² 

[1] Department of Histology, Cytology and Embryology, Kazan State Medical UniversityKazan, Russia;OpenLab Gene and Cell Technologies, Institute of Fundamental Medicine and Biology, Kazan Federal UniversityKazan, Russia;

关键词: human umbilical cord blood cells;    neuroregeneration strategies;    neurodegeneration diseases;    spinal cord injury;    stroke;   

DOI  :  10.3389/fphar.2017.00628

来源: DOAJ

【 摘 要 】

At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC), which are potentially able to replace dead cells and synthesize neurotrophic factors and other molecules that stimulate neuroregeneration. We are often faced with ethical issues when selecting a source of SC. In addition to precluding these, human umbilical cord blood (hUCB) presents a number of advantages when compared with other sources of SC. In this review, we consider the key characteristics of hUCB, the results of various studies focused on the treatment of neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis), ischemic (stroke) and traumatic injuries of the nervous system and the molecular mechanisms of hUCB-derived mononuclear and stem cells.

【 授权许可】

Unknown