Bone Marrow Adipocytes—Role in Physiology and Various Nutritional Conditions in Human and Animal Models

Nutrients

Katarzyna Piotrowska¹  Maciej Tarnowski¹ 

[1] Department of Physiology, Pomeranian Medical University in Szczecin, al. Powstancow Wlkp.72, 70-111 Szczecin, Poland;

关键词: bone marrow adipose tissue;    marrow fat;    obesity;    calorie restriction;    dietary interventions;    animal models;   

DOI  :  10.3390/nu13051412

来源: DOAJ

【 摘 要 】

In recent years, adipose tissue has attracted a lot of attention. It is not only an energy reservoir but also plays important immune, paracrine and endocrine roles. BMAT (bone marrow adipose tissue) is a heterogeneous tissue, found mostly in the medullary canal of the long bones (tibia, femur and humerus), in the vertebrae and iliac crest. Adipogenesis in bone marrow cavities is a consequence of ageing or may accompany pathologies like diabetes mellitus type 1 (T1DM), T2DM, anorexia nervosa, oestrogen and growth hormone deficiencies or impaired haematopoiesis and osteoporosis. This paper focuses on studies concerning BMAT and its physiology in dietary interventions, like obesity in humans and high fat diet in rodent studies; and opposite: anorexia nervosa and calorie restriction in animal models.

【 授权许可】

Unknown