Potential Application of MicroRNA Profiling to the Diagnosis and Prognosis of HIV-1 Infection

Frontiers in Microbiology

Bin Su¹  Hao Wu¹  Yan Liu¹  Tong Zhang¹  Weiping Zeng³  Yuping Fu⁴  Shi Lian⁴  Ping Ma⁵  Haoquan Wu⁶ 

[1] Beijing Key Laboratory for HIV/AIDS Research, Beijing, China;Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China;Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV, United States;Department of Dermatology, Xuanwu Hospital, Capital Medical University, Beijing, China;Department of Infectious Diseases and STDs, Tianjin Second People’s Hospital, Tianjin, China;Kanglin Biotech (Hangzhou) Co., Ltd., Zhejiang, China;

关键词: HIV-1;    microRNA;    disease progression;    biomarker;    immune system;   

DOI  :  10.3389/fmicb.2018.03185

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) were first identified in Caenorhabditis briggsae and later recognized as playing pivotal roles in a vast range of cellular activities. It has been shown that miRNAs are an important mechanism not only for host defense against virus but also for the establishment of viral infection. During human immunodeficiency virus type 1 (HIV-1) infection, host miRNA profiles are altered either as a host response against the virus or alternatively as a mechanism for the virus to facilitate viral replication and infection or to maintain latency. The altered miRNA profiles can be detected and quantified by various advanced assays, and potentially serve as more sensitive, accurate and cost-efficient biomarkers for HIV-1 diagnosis and disease progression than those detected by currently available standard clinical assays. Such new biomarkers are critical for optimizing treatment regimens. In this review, we focus on the potential application of miRNA profiling to the diagnosis of HIV-1 infection and the monitoring of disease progression.

【 授权许可】

Unknown