Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities

Frontiers in Physiology

Niranchan Paskaranandavadivel¹  Timothy R. Angeli¹  Shameer Sathar¹  Peng Du¹  Stefan Calder¹  Gregory O'Grady²  Leo K. Cheng³ 

[1] Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand;Department of Surgery, University of Auckland, Auckland, New Zealand;Department of Surgery, Vanderbilt University, Nashville, TN, United States;

关键词: slow wave;    GI;    multi-scale modeling;    arrhythmias;    Electrophysiology;   

DOI  :  10.3389/fphys.2017.01136

来源: DOAJ

【 摘 要 】

Gastrointestinal (GI) motility is regulated in part by electrophysiological events called slow waves, which are generated by the interstitial cells of Cajal (ICC). Slow waves propagate by a process of “entrainment,” which occurs over a decreasing gradient of intrinsic frequencies in the antegrade direction across much of the GI tract. Abnormal initiation and conduction of slow waves have been demonstrated in, and linked to, a number of GI motility disorders. A range of mathematical models have been developed to study abnormal slow waves and applied to propose novel methods for non-invasive detection and therapy. This review provides a general outline of GI slow wave abnormalities and their recent classification using multi-electrode (high-resolution) mapping methods, with a particular emphasis on the spatial patterns of these abnormal activities. The recently-developed mathematical models are introduced in order of their biophysical scale from cellular to whole-organ levels. The modeling techniques, main findings from the simulations, and potential future directions arising from notable studies are discussed.

【 授权许可】

Unknown