Two cases of neural tube defects with dolutegravir use at conception in south Brazil

Brazilian Journal of Infectious Diseases

Eduardo Sprinz¹  Fernando Rocha de Oliveira²  Regis Kreitchmann³ 

[1] Corresponding author at: 285 Prof. Annes Dias street, 4th floor, Porto Alegre, RS, Brazil.;Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, RS, Brazil;Federal University of Health Sciences of Porto Alegre, School of Medicine, Porto Alegre, RS, Brazil;

关键词: HIV;    Neural tube defects;    Pregnancy;    Dolutegravir;   

DOI  :  

来源: DOAJ

【 摘 要 】

Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.

【 授权许可】

Unknown