Effects of agavins in high fat-high sucrose diet-fed mice: an exploratory study

CyTA - Journal of Food

Argel Gastelum-Arellanez¹  Alicia Huazano-García²  Juan Vázquez-Martínez³  Mercedes G. López⁴ 

[1] Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City, Mexico;Hospital General Dr. Manuel Gea González, Mexico City, Mexico;Superior Institute of Technology of Irapuato (ITESI), TecNM, Irapuato Guanajuato, Mexico;de Estudios Avanzados del IPN, Unidad IrapuatoCentro de Investigación y, Irapuato Guanajuato, Mexico;

关键词: Obesity;    prebiotics;    microbiota;    branched fructans;    agavins;    metabolites;   

DOI  :  10.1080/19476337.2022.2082536

来源: DOAJ

【 摘 要 】

The present study was to investigate whether agavins supplementation might reduce obesity in mice fed with a high fat-high sucrose (HF-HS) diet. Mice were fed with a HF-HS diet with (HF-HS+A) or without agavins (HF-HS) supplementation. Body weight, white adipose tissue (WAT), biomarkers inflammation, gastrointestinal hormones, microbiota, and their excreted metabolites were evaluated. HF-HS+A mice significantly reduced body weight, WAT, and leptin levels compared to the HF-HS group. Furthermore, pro-inflammatory cytokines and insulin levels tended to be lower in the HF-HS+A group. Moreover, the genera Allobaculum, Akkermansia, and Sutterella, linked with positives effects on host health, were identified as possible biomarkers for agavins treatment; meanwhile, ethyl oleate, thymine, hypoxanthine, uracil, and some fatty acids were substantially enriched with agavins and negative associated with pro-inflammatory biomarkers. Collectively, these results demonstrate that agavins can ameliorates many of the harmful effects induced by intake of a diet with a high fat and sucrose content.

【 授权许可】

Unknown