Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment?

Frontiers in Psychiatry

Chuanyue Wang¹  Fude Yang²  Jingping Zhao³  Xin Zeng⁴  Yanbo Yuan⁵  Xue Han⁵  Lei Yang⁵  Xin Yu⁵  Zhang Cheng⁵  Zheng Lu⁶  Hong Deng⁷ 

[1] Beijing Anding Hospital, Capital Medical University, Beijing, China;Beijing Hui-Long-Guan Hospital, Beijing, China;Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China;Peking University Clinical Research Institute, Beijing, China;Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China;Tongji Hospital of Tongji University, Shanghai, China;West China Hospital, Sichuan University, Chengdu, China;

关键词: first-episode;    schizophrenia;    antipsychotic;    remission;    negative symptom;   

DOI  :  10.3389/fpsyt.2020.00566

来源: DOAJ

【 摘 要 】

ObjectiveTo investigate the persistent remission rate (PRR) and its predictors within the first year of antipsychotic treatment in first-episode schizophrenia (FES) patients.MethodsIn a sample of 301 FES patients who remained in antipsychotic treatment for 1 year, we assessed symptoms with the Positive and Negative Syndrome Scale (PANSS), cognition in six domains and functioning with the Personal and Social Performance Scale (PSP).ResultsIn total, 75.4% (227/301) of FES patients remaining in antipsychotic treatment reached persistent remission (PR) in one year. The PSP score was higher in remitters than non-remitters at the endpoint of the 1-year follow-up (P <0.0001). The PANSS negative score—but not the PANSS total score, positive score or general psychopathological score; PSP score; or cognitive performance at baseline—was negatively associated with PR. Lower scores for “abstract thinking” and “stereotyped thinking” were independent predictors of PR.ConclusionsIn FES, nearly 3/4 patients could achieve PR with 1 year of antipsychotic treatment, and having fewer negative symptoms, especially thinking and volition symptoms, can predict PR.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT01057849.

【 授权许可】

Unknown