New Insights into Immune-Mediated Mechanisms in Parkinson’s Disease

International Journal of Molecular Sciences

JoleneSu Yi Tan¹  Eng-King Tan¹  YinXia Chao¹  Olaf Rötzschke² 

[1] Duke-NUS Medical School, Singapore 169857, Singapore;Singapore Immunology Network (SIgN), A*STAR, Singapore 138648, Singapore;

关键词: Parkinson’s disease;    neuroinflammation;    innate and adaptive immunity;    gut-brain axis;   

DOI  :  10.3390/ijms21239302

来源: DOAJ

【 摘 要 】

The immune system has been increasingly recognized as a major contributor in the pathogenesis of Parkinson’s disease (PD). The double-edged nature of the immune system poses a problem in harnessing immunomodulatory therapies to prevent and slow the progression of this debilitating disease. To tackle this conundrum, understanding the mechanisms underlying immune-mediated neuronal death will aid in the identification of neuroprotective strategies to preserve dopaminergic neurons. Specific innate and adaptive immune mediators may directly or indirectly induce dopaminergic neuronal death. Genetic factors, the gut-brain axis and the recent identification of PD-specific T cells may provide novel mechanistic insights on PD pathogenesis. Future studies to address the gaps in the identification of autoantibodies, variability in immunophenotyping studies and the contribution of gut dysbiosis to PD may eventually provide new therapeutic targets for PD.

【 授权许可】

Unknown