Inconsistency in Abnormal Functional Connectivity Across Datasets of ADHD-200 in Children With Attention Deficit Hyperactivity Disorder

Frontiers in Psychiatry

Hong Luo¹  Yan-Tong Fang¹  Qing-Jiu Cao²  Yu-Feng Wang²  Li Sun²  Xia-Qing Lan⁴  Zhi-Wei Zhou⁴  Hang Zhang⁴  Yu-Feng Zang⁴ 

[1] Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, China;Institute of Mental Health, The Sixth Hospital, Peking University, Beijing, China;Institute of Psychological Sciences, College of Education, Hangzhou Normal University, Hangzhou, China;Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China;

关键词: attention deficit hyperactivity disorder;    resting-state fMRI;    multi-site dataset;    ADHD-200;    functional connectivity;   

DOI  :  10.3389/fpsyt.2019.00692

来源: DOAJ

【 摘 要 】

Many studies have shown abnormal functional connectivity in children with attention deficit hyperactivity disorder (ADHD) by using resting-state functional magnetic resonance imaging (rs-fMRI). However, few studies illustrated that to what extent these findings were consistent across different datasets. The present study aimed to assess the consistency of abnormal functional connectivity in children with ADHD across the four datasets from a public-assess rs-fMRI ADHD cohort, namely, ADHD-200. We employed the identical analysis process of previous studies and examined a few factors, including connectivity with the seed regions of the bilateral dorsal anterior cingulate cortex, bilateral inferior frontal gyrus, and bilateral middle frontal gyrus; connectivity between default mode network and executive control network; stringent and lenient statistical thresholds; and the ADHD subtypes. Our results revealed a high inconsistency of abnormal seed-based connectivity in children with ADHD across all datasets, even across three datasets from the same research site. This inconsistency could also be observed with a lenient statistical threshold. Besides, each dataset did not show abnormal connectivity between default mode network and executive control network for ADHD, albeit this abnormal connectivity between networks was intensively reported in previous studies. Importantly, the ADHD combined subtype showed greater consistency than did the inattention subtype. These findings provided methodological insights into the studies on spontaneous brain activity of ADHD, and the ADHD subtypes deserve more attention in future studies.

【 授权许可】

Unknown