The Concept of Indeterminable NASH Inducted by Preoperative Diet and Metabolic Surgery: Analyses of Histopathological and Clinical Features

Biomedicines

Kazuyuki Ishida¹  Tamotsu Sugai²  Masao Nishiya²  Haruka Nikai³  Naoto Takahashi³  Akira Sasaki³  Hiroyuki Nitta³  Akira Umemura³  Yasuhiro Takikawa⁴  Keisuke Kakisaka⁴  Tamami Abe⁴ 

[1] Department of DiagnosticPathology, Dokkyo Medical University, Tochigi 321-0293, Japan;Department of Pathology, Iwate Medical University, Iwate 028-3695, Japan;Department of Surgery, Iwate Medical University, Iwate 028-3695, Japan;Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Iwate 028-3695, Japan;

关键词: NAFLD;    NASH;    liver fibrosis;    hepatocyte ballooning;    metabolic surgery;   

DOI  :  10.3390/biomedicines10020453

来源: DOAJ

【 摘 要 】

Practitioners routinely perform intraoperative liver biopsies during laparoscopic sleeve gastrectomy (LSG) to evaluate nonalcoholic fatty liver disease (NAFLD). In some patients, hepatocyte ballooning, inflammation, and fibrosis without steatosis are observed, even in the absence of other etiologies. We call this finding indeterminable nonalcoholic steatohepatitis (Ind-NASH). In this study, we clarified the prevalence, as well as histopathological and clinical features, of Ind-NASH through intraoperative liver biopsy in Japanese patients presenting with severe obesity. We enrolled 63 patients who had undergone LSG and intraoperative liver biopsy. In patients diagnosed with histopathological NASH, we performed protocol liver biopsies at 6 and 12 months after LSG. We statistically analyzed these histopathological findings and clinical parameters and found the prevalence rate of Ind-NASH discovered through intraoperative biopsy to be 15.9%. Protocol liver biopsy also revealed that Ind-NASH was an intermediate condition between NASH and normal liver. The clinical features of patients with Ind-NASH are a higher body weight compared to NASH (134.9 kg vs. 114.7 kg; p = 0.0245), stronger insulin resistance compared to nonalcoholic fatty liver (homeostasis model assessment–insulin resistance: 7.1 vs. 4.9; p = 0.0188), and mild liver dysfunction compared to NASH. Patients with Ind-NASH observed positive weight-loss effects from a preoperative diet compared to the postoperative course (percentage total weight loss: 32.0% vs. 26.7%; p < 0.0001). Patients with Ind-NASH may also be good candidates for metabolic surgery owing to their good treatment response; therefore, efforts should be made by specialists in the near future to deeply discuss and define Ind-NASH.

【 授权许可】

Unknown