Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy

Frontiers in Neurology

Yung-Yang Lin¹  Syu-Jyun Peng²  Szu-Yen Pan⁷  Hsin Tung⁸  Tsuo-Hung Lan⁹ 

[1] 0Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan;1Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taiwan;Center of Faculty Development, Taichung Veterans General Hospital, Taichung, Taiwan;Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan;Division of Epilepsy, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan;Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan;

关键词: gray matter density;    thalamus;    anterior thalamic nucleus;    hippocampal-thalamic-cortical network;    temporal lobe epilepsy;   

DOI  :  10.3389/fneur.2021.810186

来源: DOAJ

【 摘 要 】

IntroductionBrain cortico-subcortical connectivity has been investigated in epilepsy using the functional MRI (MRI). Although structural images cannot demonstrate dynamic changes, they provide higher spatial resolution, which allows exploration of the organization of brain in greater detail.MethodsWe used high-resolution brain MRI to study the hippocampal-thalamic-cortical networks in temporal lobe epilepsy (TLE) using a volume-based morphometric method. We enrolled 22 right-TLE, 33 left-TLE, and 28 age/gender-matched controls retrospectively. FreeSurfer software was used for the thalamus segmentation.ResultsAmong the 50 subfields, ipsilateral anterior, lateral, and parts of the intralaminar and medial nuclei, as well as the contralateral parts of lateral nuclei had significant volume loss in both TLE. The anteroventral nucleus was most vulnerable. Most thalamic subfields were susceptible to seizure burden, especially the left-TLE. SPM12 was used to conduct an analysis of the gray matter density (GMD) maps. Decreased extratemporal GMD occurred bilaterally. Both TLE demonstrated significant GMD loss over the ipsilateral inferior frontal gyrus, precentral gyrus, and medial orbital cortices.SignificanceThalamic subfield atrophy was related to the ipsilateral inferior frontal GMD changes, which presented positively in left-TLE and negatively in right-TLE. These findings suggest prefrontal-thalamo-hippocampal network disruption in TLE.

【 授权许可】

Unknown