New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation

International Journal of Molecular Sciences

关键词: Artemia salina;    Daphnia magna;    Triticum aestivum;    pyrazolyl thiourea;   

DOI  :  10.3390/ijms141121805

来源: DOAJ

【 摘 要 】

New pyrazole derivatives were designed and synthesized as potential protein kinase inhibitors in the view to develop specific antitumor therapies. The structures of the compounds were elucidated using spectral and elemental analyses. The antitumor potential was estimated using wheat seeds and the general toxicity was evaluated by alternative methods, using invertebrate animals. One 3-aminopyrazole derivative emerged as a potential candidate for the development of future cytotoxic compounds.

【 授权许可】

Unknown