Triggers for the Nrf2/ARE Signaling Pathway and Its Nutritional Regulation: Potential Therapeutic Applications of Ulcerative Colitis

International Journal of Molecular Sciences

Hu Liu¹  Xi Ma¹  Fenglai Wang¹  Lee J. Johnston² 

[1] State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;Swine Nutrition and Production, West Central Research and Outreach Center, University of Minnesota, Morris, MN 56267, USA;

关键词: antioxidant response element;    Kelch-like ECH-associated protein 1;    nuclear factor E2-related factor 2;    nutritional regulation;    ulcerative colitis;   

DOI  :  10.3390/ijms222111411

来源: DOAJ

【 摘 要 】

Ulcerative colitis (UC), which affects millions of people worldwide, is characterized by extensive colonic injury involving mucosal and submucosal layers of the colon. Nuclear factor E2-related factor 2 (Nrf2) plays a critical role in cellular protection against oxidant-induced stress. Antioxidant response element (ARE) is the binding site recognized by Nrf2 and leads to the expression of phase II detoxifying enzymes and antioxidant proteins. The Nrf2/ARE system is a key factor for preventing and resolving tissue injury and inflammation in disease conditions such as UC. Researchers have proposed that both Keap1-dependent and Keap1-independent cascades contribute positive effects on activation of the Nrf2/ARE pathway. In this review, we summarize the present knowledge on mechanisms controlling the activation process. We will further review nutritional compounds that can modulate activation of the Nrf2/ARE pathway and may be used as potential therapeutic application of UC. These comprehensive data will help us to better understand the Nrf2/ARE signaling pathway and promote its effective application in response to common diseases induced by oxidative stress and inflammation.

【 授权许可】

Unknown