Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms

Journal of Hematology & Oncology

Farzad Tahmasebi Arashloo¹  Mostafa Ghadamzadeh²  Ladan Younesi³  Zeinab Safarpour Lima³  Ghazaleh Amjad³  Mohammad Reza Ebadi⁴ 

[1] Clinical Research Unit, Afzalipour Hospital, Kerman University of Medical Sciences;Departement of Radiology, Hasheminejad Kidney Centre (HKC), Iran University of Medical Sciences;Shahid Akbar Abadi Clinical Research Development Unit (ShCRDU), Iran University of Medical Sciences (IUMS);Shohadaye Haft-e-tir Hospital, Iran University of Medical Sciences (IUMS);

关键词: Breast;    New drug;    Chromosome;    Molecular patterns;    Mutations;   

DOI  :  10.1186/s13045-019-0725-6

来源: DOAJ

【 摘 要 】

Abstract Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Regarding the widespread multigene panels, whole exome sequencing is capable of providing the evaluation of genetic function mutations for development novel strategy in clinical trials. Targeting the mutant proteins involved in breast cancer can be an effective therapeutic approach for developing novel drugs. This systematic review discusses gene mutations linked to breast cancer, focusing on signaling pathways that are being targeted with investigational therapeutic strategies, where clinical trials could be potentially initiated in the future are being highlighted.

【 授权许可】

Unknown