Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study

Neurology International

Taro Kishi¹  Nakao Iwata¹  Yuki Konishi²  Tomoya Natsuyama²  Atsuko Ikenouchi²  Hirofumi Tesen²  Reiji Yoshimura²  Ryohei Igata²  Naomichi Okamoto²  Rintaro Fujii²  Shingo Kakeda³  Keita Watanabe⁴ 

[1] Department of Psychiatry, Fujita Health University, Toyoake 470-1192, Japan;Department of Psychiatry, Hospital of University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan;Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8560, Japan;Open Innovation Institute, Kyoto University, Kyoto 606-8501, Japan;

关键词: amygdala;    subregions;    major depressive disorder;    brain-derived neurotrophic factor;    cortisol;    serotonin transporter gene polymorphism;   

DOI  :  10.3390/neurolint14020031

来源: DOAJ

【 摘 要 】

The amygdala is a prominent region of the brain that plays a critical role in the pathophysiology of major depressive disorder (MDD). The amygdala is formed from a collection of interconnected substructures (nuclei) that relay signals from multiple brain areas, which suggests that the amygdala has different functions depending on its subregion. There are two main alleles of serotonin transporter gene polymorphism (5-HTTLPR): a 44-bp insertion (l-allele) or deletion (s-allele). The transcriptional activity of the l-allele of the gene is twice that of the s-allele. The present study aimed to investigate the association between the volume of the whole amygdala and subregions of the amygdala in 25 first-episode and drug-naive patients with MDD and 46 healthy controls (HCs) with the s/s genotype of 5-HTTLPR and plasma levels of brain-derived neurotrophic factor (BDNF) or cortisol. No significant difference was observed in the amygdala total and subregion volumes between the HC and MDD groups. No significant difference was found in the plasma levels of BDNF and cortisol between the two groups. In addition, no correlations were found between the total and subregion amygdala volume and plasma levels of cortisol or BDNF.

【 授权许可】

Unknown