Anti-inflammatory effect of stem cells against spinal cord injury via regulating macrophage polarization

Journal of Neurorestoratology

关键词: stem cells;    macrophages;    Spinal cord injury;    Polarization;   

DOI  :  

来源: DOAJ

【 摘 要 】

Zhijian Cheng, Xijing He Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Abstract: Spinal cord injury (SCI) is a traumatic event that involves not just an acute physical injury but also inflammation-driven secondary injury. Macrophages play a very important role in secondary injury. The effects of macrophages on tissue damage and repair after SCI are related to macrophage polarization. Stem cell transplantation has been studied as a promising treatment for SCI. Recently, increasing evidence shows that stem cells, including mesenchymal stem, neural stem/progenitor, and embryonic stem cells, have an anti-inflammatory capacity and promote functional recovery after SCI by inducing macrophages M1/M2 phenotype transformation. In this review, we will discuss the role of stem cells on macrophage polarization and its role in stem cell-based therapies for SCI. Keywords: stem cells, macrophages, spinal cord injury, polarization

【 授权许可】

Unknown