Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles

Molecules

Federica Foglietta¹  Roberto Canaparo¹  Carlo Della Pepa¹  Franco Dosio¹  Loredana Serpe¹  Francesca Giuntini² 

[1] Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy;School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 2AJ, UK;

关键词: nanoparticles;    drug delivery systems;    antibiotics drug delivery systems;    stimuli-responsive nanoparticles;    stimuli-responsive antibiotic-loaded nanoparticles;    nanoantibiotics;    stimuli-responsive nanoantibiotics;    multi-drug resistant bacteria;    bacterial biofilms;   

DOI  :  10.3390/molecules24101991

来源: DOAJ

【 摘 要 】

Conventional drugs used for antibacterial therapy display several limitations. This is not due to antibiotics being ineffective, but rather due to their low bioavailability, limited penetration to sites of infection and the rise of drug-resistant bacteria. Although new delivery systems (e.g., nanoparticles) that are loaded with antibacterial drugs have been designed to overcome these limitations, therapeutic efficacy does not seem to have improved. Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. These stimuli can either be exogenous (e.g., light, ultrasound) or endogenous (e.g., pH, variation in redox gradient, enzymes). This promising therapeutic approach relies on advances in materials science and increased knowledge of microorganism growth and biofilm formation. This review provides an overview in the field of antibacterial drug-delivery systems and nanoantibiotics that benefit from a response to specific triggers, and also presents a number of future prospects.

【 授权许可】

Unknown