E‐cigarette or Vaping Product Use–Associated Lung Injury Produced in an Animal Model From Electronic Cigarette Vapor Exposure Without Tetrahydrocannabinol or Vitamin E Oil

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

David Herman¹  Amanda Ting¹  Irene Hasen¹  Rebecca Johnson Arechavala¹  Michael T. Kleinman¹  Lifu Zhao²  Wangde Dai²  Jianru Shi²  Juan Carreno²  Jesus Chavez²  Robert A. Kloner² 

[1]Department of Medicine University of California Irvine CA

[2]HMRI Cardiovascular Research InstituteHuntington Medical Research Institutes Pasadena CA

关键词: E‐cigarette;    lung;    lung injury;    pneumonitis;    respiratory distress;    vaping;   

DOI  :  10.1161/JAHA.120.017368

来源: DOAJ

【 摘 要 】

Abstract E‐cigarette or vaping product use–associated lung injury was recognized in the United States in the summer of 2019 and is typified by acute respiratory distress, shortness of breath, chest pain, cough, and fever, associated with vaping. It can mimic many of the manifestations of coronavirus disease 2019 (COVID‐19). Some investigators have suggested that E‐cigarette or vaping product use–associated lung injury was due to tetrahydrocannabinol or vitamin E acetate oil mixed with the electronic cigarette liquid. In experimental rodent studies initially designed to study the effect of electronic cigarette use on the cardiovascular system, we observed an E‐cigarette or vaping product use–associated lung injury‐like condition that occurred acutely after use of a nichrome heating element at high power, without the use of tetrahydrocannabinol, vitamin E, or nicotine. Lung lesions included thickening of the alveolar wall with foci of inflammation, red blood cell congestion, obliteration of alveolar spaces, and pneumonitis in some cases; bronchi showed accumulation of fibrin, inflammatory cells, and mucus plugs. Electronic cigarette users should be cautioned about the potential danger of operating electronic cigarette units at high settings; the possibility that certain heating elements may be deleterious; and that E‐cigarette or vaping product use–associated lung injury may not be dependent upon tetrahydrocannabinol, vitamin E, or nicotine.

【 授权许可】

Unknown