Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study)

Molecular Genetics & Genomic Medicine

Enrique Juárez‐Cedillo¹  Teresa Juárez‐Cedillo²  Nancy Martínez‐Rodríguez³  Jorge Escobedo‐de‐la‐Peña⁴  José Manuel Fragoso⁴  Gilberto Vargas‐Alarcón⁴ 

[1] (SSA) Mexico City Mexico;Comisionada en la Unidad de investigación en Epidemiologia Clínica, Hospital Regional No. 1, Dr. Carlos McGregor Sánchez Navarro, Instituto Mexicano del Seguro Social Mexico City Mexico;Community Health Research. Department Hospital Infantil de Mexico Federico Gomez;Departamento de Biología Molecular. Instituto Nacional de Cardiología Ignacio Chávez, (SSA) Mexico City Mexico;

关键词: frailty;    geriatric syndrome;    haplotypes;    interleukin;    polymorphisms;   

DOI  :  10.1002/mgg3.918

来源: DOAJ

【 摘 要 】

Abstract Frailty is a geriatric syndrome, characterized by a loss in functional reserve with an increase in morbidity and mortality. There are no reports that link the genetic polymorphisms between interleukin 10 (IL10) and frailty; for this reason, our objective was used to analyze the role of the polymorphisms of IL10 (rs1800896, rs1800871) in the susceptibility to frailty in a Mexican population. Our study included 984 participants divided into 368 nonfrail, 309 prefrail, and 307 frail. The models for the polymorphisms rs1800896 and rs1800871 were recessive models in association with frailty (OR = 2.3, CI 95% = 1.6–3.2; OR = 1.53, CI 95% = 1.0–2.6), respectively. Two risk haplotypes were identified: ACG and CCG (p < .0001), and three protective haplotypes were identified: ACA, ATG, and ATA (p < .05). This study evaluated the relationship between IL10 and the three subtypes of this geriatric syndrome (frail, prefrail, and nonfrail). These results support a greater susceptibility to frailty for the minor alleles of rs1800871 and rs1800896. In addition, we found two risk haplotypes supporting the participation of the IL10 in the susceptibility for frailty in the Mexican population.

【 授权许可】

Unknown