Microvascular changes and the mechanism in Alzheimer's disease

Chinese Journal of Contemporary Neurology and Neurosurgery

Yu-jun YUAN¹  Xi-mei HU¹  Ying MA¹ 

[1] Department of Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China;

关键词: Alzheimer disease;    Vascular endothelial growth factors;    Oxidative stress;    Amyloid;    Review;   

DOI  :  

来源: DOAJ

【 摘 要 】

Till now, the pathogenic mechanism of Alzheimer's disease (AD) is notcompletely clear. Extensive literatures have shown that the local cerebralmicrovascular disease occurs before neurodegeneration and cognitive impairment,and local blood flow reduction happens before the clinical symptoms of AD. Thisreveals that the microvascular changes are probably the important pathogenicmanifestation in the AD formation and involved in the occurrence and developmentof AD. In this review, we explore the possible pathogenic mechanism of AD byanalyzing the morphological changes of microvasculature, and the effects ofvascular endothelial growth factor (VEGF), oxidative stress and amyloidβ-protein (Aβ) on microvasculature respectively.

 

DOI: 10.3969/j.issn.1672-6731.2016.05.011

【 授权许可】

Unknown