Radiation and Thyroid Cancer

International Journal of Molecular Sciences

Francesco Curcio¹  Francesco Saverio Ambesi-Impiombato¹  Samuela Cataldi²  Michela Codini²  Tommaso Beccari²  Elisabetta Albi²  Andrea Lazzarini³ 

[1] Department of Clinical and Biological Sciences, University of Udine, 33100 Udine, Italy;Department of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy;Research Center and Analysis Laboratory CRABiON, 06073 Perugia, Italy;

关键词: radiation;    thyroid cancer;    cancer genes;    lipid metabolism;   

DOI  :  10.3390/ijms18050911

来源: DOAJ

【 摘 要 】

Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets.

【 授权许可】

Unknown