Relationship between hemoglobin and insulin-like growth factor-1 in children and adolescents with idiopathic short stature

BMC Endocrine Disorders

Hui Pan¹  Bo Ban²  Wenhua Yan²  Qianqian Zhao²  Mei Zhang²  Baolan Ji²  Yuntian Chu³ 

[1]Chinese Research Center for Behavior Medicine in Growth and Development

[2]Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University

[3]School of Health Management and Medicine, Tongji Medical College, Huazhong University of Science and Technology

关键词: Insulin-like growth factor-1;    Hemoglobin;    Idiopathic short stature;   

DOI  :  10.1186/s12902-020-00600-w

来源: DOAJ

【 摘 要 】

Abstract Background The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis is critical for the regulation of children’s growth and development. Serum IGF-1 concentrations are usually low in individuals with idiopathic short stature (ISS) despite normal endogenous GH levels, and the associated underlying factors are unknown. This study aimed to explore the relationship between IGF-1 and hemoglobin (Hb) in children with ISS. Methods A cross-sectional analysis was performed including 178 children and adolescents with ISS who were enrolled from March 2013 to February 2019. The related clinical and biochemical parameters were evaluated for each patient. Univariate analysis, smooth curve fitting and multivariate piecewise linear regression were performed. Result The mean levels of IGF-1 standard deviation scores (SDS) and Hb were − 0.99 (− 1.60 - -0.09) and 131.81 ± 9.36 g/L, respectively. Univariate analysis displayed a significant positive association between Hb and IGF-1 SDS (P < 0.001). After adjusting for potential confounding factors, the positive relationship between Hb and IGF-1 SDS remained (P = 0.001). Furthermore, there was an inflection point for Hb in the curve. In a multivariate piecewise linear regression model, IGF-1 SDS was significantly positively associated with Hb when Hb concentrations were lower than 145 g/L (B 0.05; 95% CI 0.02, 0.07; P < 0.001). However, IGF-1 SDS decreased with increasing Hb levels when Hb concentrations were greater than 145 g/L (B -0.15; 95% CI -0.23, − 0.06; P = 0.001). Conclusion This study demonstrated that Hb is associated with IGF-1 in Chinese children and adolescents with ISS. The levels of IGF-1 increased with the elevation of Hb, but when the concentration of Hb exceeded a certain range, with the increase of Hb, IGF-1 decreased instead.

【 授权许可】

Unknown