Alpha oscillations predict paroxetine response to low sexual desire in depression

Journal of Affective Disorders Reports

Reyhan İlhan¹  Özden Öksüz²  Barış Metin³  Mehmet Kemal Arıkan⁴  Güven Günver⁴  Şenol Turan⁵ 

[1] Corresponding author at: Halaskargazi caddesi No: 103, Gün Apt., kat. 4B, Osmanbey/Istanbul 34371, Turkey.;Department of Biostatistics, Faculty of Medicine, University of Istanbul, Istanbul Turkey;Department of Psychiatry, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul Turkey;Kemal Arıkan Psychiatry Clinic, Istanbul, Turkey;Yeditepe University, Istanbul Turkey;

关键词: Alpha oscillations;    Depression;    Libido;    Paroxetine;    QEEG;    Sexual desire;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Decreased sexual desire (libido) is one of the most common sexual complaints in patients with depression. It is known that antidepressants have certain effects on sexual life. Paroxetine is one of those antidepressants. However, the sexual adverse effects of paroxetine are unpredictable. This retrospective study aimed at determining the electrophysiological markers of paroxetine treatment effect on sexual desire in patients with depression (N = 56). Methods: Quantitative electroencephalography (QEEG) spectral power across all frequency bands were examined in depressed patients with decreased or normal sexual desire. Analysis of covariance was conducted on baseline qEEG, taking attention condition and severity of depression (Hamilton Depression Rating Scale -HDRS) as covariates. Results: Patients whose sexual desire did not improve had higher frontal alpha power and impaired attention function at baseline examination. Limitations: The results could be taken as preliminary due to the modest sample size. Conclusion: Based on the present findings, it can be concluded that frontal alpha power can be a biomarker of lack of libido improvement after treatment with paroxetine.

【 授权许可】

Unknown