Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: A review of literature

Taiwanese Journal of Obstetrics & Gynecology

Mozhdeh Momtahan¹  Majid Fardaei²  Zahra Anvar³  Najmeh Moein-Vaziri³  Bahia Namavar-Jahromi³  Jafar Fallahi⁴ 

[1] Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Genetics Department, Shiraz University of Medical Sciences, Shiraz, Iran;Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Molecular Medicine Department, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Gestational trophoblastic disease;    Hydatidiform Mole;    KHDC3L;    Maternal effect genes;    NLRP7;   

DOI  :  10.1016/j.tjog.2017.12.001

来源: DOAJ

【 摘 要 】

Hydatidiform Mole (HM) is the most common form of Gestational Trophoblastic Disease (GTD), defined by hyper-proliferation of trophoblastic cells. HM is typified as abnormal proliferation of extraembryonic trophoblastic (placental) tissues and failure of embryonic tissues development and is the only GTD with Mendelian inheritance, which can reoccur in different pregnancies. Moles are categorized into Complete Hydatidiform Moles (CHM) or Partial Hydatidiform Moles (PHM) and a rare familial trait, which forms a CHM and despite having androgenetic pattern, shows normal biparental inheritance, conceived from one sperm and egg. Recessive maternal-effect mutations in NLRP7 (NACHT, leucine rich repeat and PYD containing 7) and KHDC3L (KH Domain Containing 3-Like) genes have been shown to be responsible for Recurrent Hydatidiform Moles (HYDM1 MIM# 231090 when is caused by mutation in the NLRP7 gene and HYDM2 MIM#614293 when is caused by mutation in the KHDC3L gene). Methylation aberration in multiple maternally imprinted genes is introduced as the cause of Recurrent HYDM pathology. The current article reviews the histopathology, risk factors, and genetic and epigenetic characteristics of Recurrent HYDMs.

【 授权许可】

Unknown