Ameliorative effect of alpha lipoic acid and royal jelly against the side effects of cyclophosphamide in liver of albino rats

Beni-Suef University Journal of Basic and Applied Sciences

Nadia Moustafa¹  Manal Abdul-Hamid¹  Amal M. Abukhadra¹  Khalid A. El-Nesr² 

[1] Department of Zoology, Faculty of Science, Beni-Suef University;Pathology Department, Faculty of Veterinary Medicine, Beni-Suef University;

关键词: Cyclophosphamide;    Alpha-lipoic acid;    Royal jelly;    Antioxidant;    ALT;    AST;   

DOI  :  10.1186/s43088-020-00042-2

来源: DOAJ

【 摘 要 】

Abstract Background Cyclophosphamide (CP) is a cytotoxic anticancer drug used for the treatment of neoplastic diseases. The present study aimed to examine biochemical, histological, and ultrastructural effects of CP on rat liver and determine the hepatoprotective effects of alpha-lipoic acid (LA) or royal jelly (RJ) against CP. Results The present study revealed that CP-induced significant increase in hepatic marker enzymes (ALT and AST), and elevation in malonaldehyde (MDA) was concomitant with a significant decrease of superoxide dismutase (SOD). It caused histopathological changes in the liver of rat including vacuolation, infiltration, degeneration, and necrosis. Ultrastructurally, the hepatocytes appeared degenerated with multiple small- and medium-sized lipid droplets in the cytoplasm. Kupffer cell showed a shrunken nucleus. Administration of LA and RJ resulted in an obvious improvement in the altered level of ALT, AST, MDA, and SOD activities when compared with the CP-treated group in addition to marked amelioration in histopathology and ultrastructure of the liver. Conclusions LA is markedly effective than RJ in protecting rats against CP-induced biochemical, histopathological, and ultrastructural changes. This protection may be due to its antioxidant properties and scavenging abilities against active free radicals.

【 授权许可】

Unknown