A Review on Microfluidic Platforms Applied to Nerve Regeneration

Applied Sciences

Xiaoming Liu¹  Jiping He¹  Chuankai Dai¹  Rongyu Tang¹  Tatsuo Arai¹ 

[1] Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing 100081, China;

关键词: microfluidic device;    nerve regeneration;    nerve repair;    axon regrowth;    neurite outgrowth;    axon guidance;   

DOI  :  10.3390/app12073534

来源: DOAJ

【 摘 要 】

In recent decades, microfluidics have significantly advanced nerve regeneration research. Microfluidic devices can provide an accurate simulation of in vivo microenvironment for different research purposes such as analyzing myelin growth inhibitory factors, screening drugs, assessing nerve growth factors, and exploring mechanisms of neural injury and regeneration. The microfluidic platform offers technical supports for nerve regeneration that enable precise spatio-temporal control of cells, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance. In this paper, we review the development and recent advances of microfluidic platforms for nerve regeneration research.

【 授权许可】

Unknown