Patient Derived Ex-Vivo Cancer Models in Drug Development, Personalized Medicine, and Radiotherapy

Cancers

Rishi Man Chugh¹  Subhrajit Saha¹  Ryan Zitter¹ 

[1] Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA;

关键词: patient-derived organoids;    organ-in-chip;    cancer models;    drug development;    personalized medicine;    radiotherapy;   

DOI  :  10.3390/cancers14123006

来源: DOAJ

【 摘 要 】

The field of cancer research is famous for its incremental steps in improving therapy. The consistent but slow rate of improvement is greatly due to its meticulous use of consistent cancer biology models. However, as we enter an era of increasingly personalized cancer care, including chemo and radiotherapy, our cancer models must be equally able to be applied to all individuals. Patient-derived organoid (PDO) and organ-in-chip (OIC) models based on the micro-physiological bioengineered platform have already been considered key components for preclinical and translational studies. Accounting for patient variability is one of the greatest challenges in the crossover from preclinical development to clinical trials and patient derived organoids may offer a steppingstone between the two. In this review, we highlight how incorporating PDO’s and OIC’s into the development of cancer therapy promises to increase the efficiency of our therapeutics.

【 授权许可】

Unknown