COVID-19 and SARS-CoV-2 Variants: Current Challenges and Health Concern

Frontiers in Genetics

Abdullah M. AlShahrani¹  Md. Zeyaullah¹  Wajihul Hasan Khan²  Razi Ahmad³  Shane Alam⁴  Khursheed Muzammil⁵  Irfan Ahmad⁶ 

[1] Department of Basic Medical Science, College of Applied Medical Sciences, King Khalid University (KKU), Abha, Saudi Arabia;Department of Chemical Engineering, Indian Institute of Technology Delhi, New Delhi, India;Department of Chemistry, Indian Institute of Technology Delhi, New Delhi, India;Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University (JU), Jizan, Saudi Arabia;Department of Public Health, College of Applied Medical Sciences, King Khalid University (KKU), Abha, Saudi Arabia;Genomic Science Academy, Muzaffarpur, India;

关键词: COVID-19;    SARS-CoV-2 variant;    therapeutics;    vaccine efficacy;    wave of infection;   

DOI  :  10.3389/fgene.2021.693916

来源: DOAJ

【 摘 要 】

The ongoing coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, was triggered and unfolded quickly throughout the globe by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The new virus, transmitted primarily through inhalation or contact with infected droplets, seems very contagious and pathogenic, with an incubation period varying from 2 to 14 days. The epidemic is an ongoing public health problem that challenges the present global health system. A worldwide social and economic stress has been observed. The transitional source of origin and its transport to humans is unknown, but speedy human transportation has been accepted extensively. The typical clinical symptoms of COVID-19 are almost like colds. With case fatality rates varying from 2 to 3 percent, a small number of patients may experience serious health problems or even die. To date, there is a limited number of antiviral agents or vaccines for the treatment of COVID-19. The occurrence and pathogenicity of COVID-19 infection are outlined and comparatively analyzed, given the outbreak’s urgency. The recent developments in diagnostics, treatment, and marketed vaccine are discussed to deal with this viral outbreak. Now the scientist is concerned about the appearance of several variants over the globe and the efficacy of the vaccine against these variants. There is a need for consistent monitoring of the virus epidemiology and surveillance of the ongoing variant and related disease severity.

【 授权许可】

Unknown