Tumor-Associated Macrophage Status in Cancer Treatment

Cancers

Simona Pisanti¹  Rosanna Martinelli¹  AnnaMaria Malfitano²  Giuseppe Portella²  Sarah Di Somma²  Fabiana Napolitano² 

[1] Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via Salvador Allende, Baronissi, 84081 Salerno, Italy;Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy;

关键词: tumor-associated macrophages;    chemotherapy;    radiotherapy;    immune-checkpoint blocking therapy;    oncolytic virus;    virotherapy;   

DOI  :  10.3390/cancers12071987

来源: DOAJ

【 摘 要 】

Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration is generally associated with poor prognosis, but macrophages are highly plastic cells that can adopt either proinflammatory/antitumor or anti-inflammatory/protumor features in response to tumor microenvironment stimuli. In the context of cancer therapy, many anticancer therapeutics, apart from their direct effect on tumor cells, display different effects on TAM activation status and density. In this review, we aim to evaluate the indirect effects of anticancer therapies in the modulation of TAM phenotypes and pro/antitumor activity.

【 授权许可】

Unknown