Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology

Bioactive Materials

Ling Qin¹  Yulong Tang²  Yue Li²  Ling Ren³  Shuyuan Zhang³  Xinluan Wang³  Zijian Wang⁴  Hui Liu⁴  Huan Liu⁵  Ke Yang⁶ 

[1] Musculoskeletal Research Laboratory of Department of Orthopaedics &Shi-changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang, 110016, China;Department of Stomatology, General Hospital of Northern Military Area, 83 Wenhua Road, Shenyang, 110016, China;School of Materials Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, China;Shi-changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang, 110016, China;Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518057, China;

关键词: Titanium-copper alloy implants;    Anti-infection;    Oral microbiology;    Biosafety;   

DOI  :  

来源: DOAJ

【 摘 要 】

This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria.

【 授权许可】

Unknown