Toward the Specificity of Bare Nanomaterial Surfaces for Protein Corona Formation

International Journal of Molecular Sciences

Massimiliano Magro¹  Fabio Vianello¹  Alessandro Cecconello¹ 

[1] Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Legnaro, Italy;

关键词: nanoparticles;    biomolecules;    protein corona;    uncoated nanomaterials;    surface recognition;   

DOI  :  10.3390/ijms22147625

来源: DOAJ

【 摘 要 】

Aiming at creating smart nanomaterials for biomedical applications, nanotechnology aspires to develop a new generation of nanomaterials with the ability to recognize different biological components in a complex environment. It is common opinion that nanomaterials must be coated with organic or inorganic layers as a mandatory prerequisite for applications in biological systems. Thus, it is the nanomaterial surface coating that predominantly controls the nanomaterial fate in the biological environment. In the last decades, interdisciplinary studies involving not only life sciences, but all branches of scientific research, provided hints for obtaining uncoated inorganic materials able to interact with biological systems with high complexity and selectivity. Herein, the fragmentary literature on the interactions between bare abiotic materials and biological components is reviewed. Moreover, the most relevant examples of selective binding and the conceptualization of the general principles behind recognition mechanisms were provided. Nanoparticle features, such as crystalline facets, density and distribution of surface chemical groups, and surface roughness and topography were encompassed for deepening the comprehension of the general concept of recognition patterns.

【 授权许可】

Unknown