Translation-Targeting RiPPs and Where to Find Them

Frontiers in Genetics

Dmitry Bikmetov¹  Dmitrii Y. Travin³  Konstantin Severinov⁵ 

[1] Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia;Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia;Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia;Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia;Waksman Institute for Microbiology, Rutgers, Piscataway, NJ, United States;

关键词: RiPPs;    ribosome;    antibiotics;    LAPs;    YcaO;    azol(in)e-modified peptides;   

DOI  :  10.3389/fgene.2020.00226

来源: DOAJ

【 摘 要 】

Prokaryotic translation is among the major targets of diverse natural products with antibacterial activity including several classes of clinically relevant antibiotics. In this review, we summarize the information about the structure, biosynthesis, and modes of action of translation inhibiting ribosomally synthesized and post-translationally modified peptides (RiPPs). Azol(in)e-containing RiPPs are known to target translation, and several new compounds inhibiting the ribosome have been characterized recently. We performed a systematic search for biosynthetic gene clusters (BGCs) of azol(in)e-containing RiPPs. This search uncovered several groups of clusters that likely direct the synthesis of novel compounds, some of which may be targeting the ribosome.

【 授权许可】

Unknown