Comparison of Endometrial Thickness with Concomitant Administration of Sildenafil Citrate and Ethinyl Estradiol vs Ethinyl Estradiol Alone for Frozen Embryo Transfer

Journal of Clinical and Diagnostic Research

Tayebe Artimani¹  Mahnaz Yavangi²  Saeid Heidari-Soureshjani³  Artimis Sadeghian⁴ 

[1] Assistant Professor, Department of Anatomy, Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.;Associate Professor, Department of Obstetrics and Gynaecology, Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.;MSc, Deputy of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran.;Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.;

关键词: endometrial thickness;    ethiniosuronidol;    infertility;   

DOI  :  10.7860/JCDR/2019/39619.12515

来源: DOAJ

【 摘 要 】

Introduction: Infertility is one of the common medical issues in today’s world. One of the common causes of infertility is the lack of implantation of the embryo. Aim: To compare the effect of Ethinyl Estradiol (E2) alone on Endometrial Thickness (ET) with that of sildenafil citrate and E2 combination. Materials and Methods: In this clinical trial, 70 infertile women undergoing treatment with Assisted Reproductive Techniques (ARTs) were randomly divided into two groups of 35 each. One group received E2 and vaginal sildenafil and the other E2 alone. On the seventh day of the cycle and, if necessary, until ET reached 8 mm, ET in both groups was measured by transvaginal ultrasound. After the embryo transfer, Beta-Human Chorionic Gonadotropin (BHCG) was performed in both groups. The measured thickness of uterus and BHCG were recorded in the checklist for both groups. Data were analysed by SPSS and p<0.05 was considered significant. Results: The mean duration (in days) to reach an 8 mm ET in infertile women in the E2+sildenafil group (13.59±3.07) was lower than that in the E2 group (14.88±4.78), yet insignificant (p=0.21). Although the mean dose (mg) of E2 and duration (day) to reach an 8 mm ET in the E2+sildenafil group was lower than those in the E2 group, significance (p) levels were 0.02 and 0.21, respectively. Conclusion: In infertile women undergoing ARTs, coadministration of sildenafil citrate and E2 increased ET relatively and reduced the dose of E2 and the duration of its administration.

【 授权许可】

Unknown