COVID-19–Related Glomerulopathy: A Report of 2 Cases of Collapsing Focal Segmental Glomerulosclerosis

Kidney Medicine

Varun Malhotra¹  Prasad Bichu²  Siddharth Khanna²  Yanglin Hu³  Sandeep Magoon³  Kabaye Berhanu⁴  Fatema Alhashimi⁵ 

[1] Address for Correspondence: Sandeep Magoon, MD, 6160 Kempsville Circle, Ste 302, Norfolk, VA 23502.;Nephrology Associate of Tidewater, Norfolk, VA;Division of Nephrology, Eastern Virginia Medical School, Norfolk, VA;Division of Nephropathology, University of North Carolina, Chapel Hill, NC;Nephrology Associate of Tidewater, Norfolk, VA;

关键词: COVID;    collapsing;    glomerulopathy;    FSGS;    SARS;    proteinuria;   

DOI  :  

来源: DOAJ

【 摘 要 】

Coronavirus disease 19 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with acute kidney injury, presumably due to acute tubular injury. However, this does not explain proteinuria, sometimes severe, and hematuria often observed. We present 2 African American patients with glomerulopathy demonstrated by kidney biopsy in the setting of acute kidney injury and COVID-19 infection. Kidney biopsy specimens showed a collapsing variant of focal segmental glomerulosclerosis in addition to acute tubular injury. Both patients were homozygous for apolipoprotein L1 (APOL1). COVID-19 infection likely caused the interferon surge as a second hit causing podocyte injury leading to collapsing focal segmental glomerulosclerosis. APOL1 testing should be strongly considered in African American patients with nephrotic-range proteinuria. More data from future kidney biopsies will further elucidate the pathology of kidney injury and glomerular involvement from COVID-19 infections.

【 授权许可】

Unknown