Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers

International Journal of Environmental Research and Public Health

DebraL. Laskin¹  VasanthiR. Sunil¹  KinalN. Vayas¹  Jessica Cervelli¹  Malik Deen²  Jag Sunderram²  Jared Radbel²  Sabiha Hussain²  Iris Udasin³  Robert Laumbach³  Howard Kipen³  JeffreyD. Laskin³ 

[1] Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA;Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA;School of Public Health, Rutgers University, Piscataway, NJ 08854, USA;

关键词: WTC;    fibrotic sarcoid;    injury;    inflammation;    fibrosis;   

DOI  :  10.3390/ijerph16050815

来源: DOAJ

【 摘 要 】

Sarcoid-like granulomatous diseases (SGD) have been previously identified in cohorts of World Trade Center (WTC) dust-exposed individuals. In the present studies, we analyzed lung and/or lymph node biopsies from patients referred to our clinic with suspected WTC dust-induced lung disease to evaluate potential pathophysiologic mechanisms. Histologic sections of lung and/or lymph node samples were analyzed for markers of injury, oxidative stress, inflammation, fibrosis, and epigenetic modifications. Out of seven patients examined, we diagnosed four with SGD and two with pulmonary fibrosis; one was diagnosed later with SGD at another medical facility. Patients with SGD were predominantly white, obese men, who were less than 50 years old and never smoked. Cytochrome b5, cytokeratin 17, heme oxygenase-1, lipocalin-2, inducible nitric oxide synthase, cyclooxygenase 2, tumor necrosis factor α, ADP-ribosylation factor-like GTPase 11, mannose receptor-1, galectin-3, transforming growth factor β, histone-3 and methylated histone-3 were identified in lung and lymph nodes at varying levels in all samples examined. Three of the biopsy samples with granulomas displayed peri-granulomatous fibrosis. These findings are important and suggest the potential of WTC dust-induced fibrotic sarcoid. It is likely that patient demographics and/or genetic factors influence the response to WTC dust injury and that these contribute to different pathological outcomes.

【 授权许可】

Unknown