Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case

OpuholiŽenskoj Reproduktivnoj Sistemy

O.  V. Kovalev¹  S. V. Vtorushin²  O.  V. Shpileva²  E. V. Kaigorodova²  A. L.  Chernyshova³ 

[1] Siberian State Medical University;Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences;Siberian State Medical University;

关键词: low-grade ovarian serous carcinoma;    ascitic tumor cells;    tumor heterogeneity;    epcam;    multicolor flow cytometry;    liquid biopsy;   

DOI  :  10.17650/1994-4098-2021-17-4-90-95

来源: DOAJ

【 摘 要 】

Ovarian cancer is one of the most malignant and aggressive tumors of the female reproductive system. Late diagnosis is one of the most significant problems: more than two-thirds of cases are detected only at stage III–IV. Ovarian cancer is characterized by a unique metastatic process. Implantation is the earliest and most common way of metastasis. It is often accompanied by fluid accumulation in the abdominal cavity, known as ascites. We report a case of low-grade serous ovarian carcinoma with a large heterogeneity of tumor cells in the ascitic fluid detected using multicolor flow cytometry. We demonstrated the advantages and benefits of this method in the diagnosis of ovarian cancer. Multicolor flow cytometry opens new horizons for liquid biopsy in oncology.

【 授权许可】

Unknown