Temporal trends in the epidemiology of inflammatory bowel diseases in the public healthcare system in Brazil: A large population-based study

The Lancet Regional Health. Americas

Aderson O.M.C. Damiao¹  Douglas A. Valverde²  Gilaad G. Kaplan³  Remo Panaccione⁴  Abel B. Quaresma⁵  Paulo G. Kotze⁶  Stephanie B. Coward⁶  Siew C. Ng⁶  Daniela O. Magro⁷  Adriano A.F. Hino⁷  Claudio S.R. Coy⁸ 

[1] Corresponding author.;Catholic University of Paraná, Health Sciences Postgraduate Program, Curitiba, Brazil;Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China;Techtrials Healthcare, Data Science, Vinhedo, Brazil;Universidade do Oeste de Santa Catarina, UNOESC, Colorectal Surgery, Joaçaba, Brazil;University of Calgary, Department of Medicine, Division of Gastroenterology and Hepatology, Calgary, Canada;University of Campinas UNICAMP, Colorectal Surgery Unit, Campinas, Brazil;University of Sao Paulo, Gastroenterology, São Paulo, Brazil;

关键词: Incidence;    Prevalence;    Inflammatory bowel disease;    Ulcerative colitis;    Crohn's disease;    Epidemiology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary:Background: Population-based data on epidemiology of Inflammatory Bowel Diseases (IBD) in Brazil are scarce. This study aims to define temporal trends of incidence and prevalence rates of Crohn's disease (CD) and ulcerative colitis (UC) in Brazil. Methods: All IBD patients from the public healthcare national system were included from January 2012 to December 2020. Average Annual Percent Change (AAPC) and 95% confidence intervals (CI) were calculated using log-linear regression for incidence and binomial regression for prevalence. Moran's I autocorrelation index was used to analyse clustering of cities by level of prevalence. Findings: A total of 212,026 IBD patients were included. Incidence of IBD rose from 9.4 in 2012 to 9.6 per 100,000 in 2020 (AAPC=0.8%; 95% CI -0.37, 1.99); for UC, incidence increased from 5.7 to 6.9 per 100,000 (AAPC=3.0%; 95% CI 1.51, 4.58) and for CD incidence decreased from 3.7 to 2.7 per 100,000 (AAPC=-3.2%; 95% CI -4.45, -2.02). Prevalence of IBD increased from 30.0 in 2012 to 100.1 per 100,000 in 2020 (AAPC=14.8%; CI 14.78-14.95); for UC, from 15.7 to 56.5 per 100,000 (AAPC=16.0%; CI 15.94, 16.17); for CD from 12.6 to 33.7 per 100,000 (AAPC=12.1% CI 11.95, 12.02). A south-north gradient was observed in 2020 prevalence rates of IBD [I=0.40 (p<0.0001)], CD [I=0.22 (p<0.0001)] and UC [I=0.42 (p<0.0001)]. Interpretation: Incidence of CD is decreasing whereas of UC is increasing, leading to stabilization in the incidence of IBD from 2012 to 2020 in Brazil. Prevalence of IBD has been climbing with 0.1% of Brazilians living with IBD in 2020. Funding: None.

【 授权许可】

Unknown