MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings

Nanomaterials

Eva Baranovicova¹  Oliver Strbak¹  Martina Kmetova²  Dusan Dobrota²  Iryna Antal³  Martina Koneracka³  Vlasta Zavisova³  Iryna Khmara³  Martina Kubovcikova³ 

[1] Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia;Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia;Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia;

关键词: magnetic nanoparticles;    maghemite;    functionalisation;    mri;    relaxivity;    amino acid;    glycine;    lysine;    tryptophan;   

DOI  :  10.3390/nano10020394

来源: DOAJ

【 摘 要 】

In this study, we analysed the physico-chemical properties of positively charged magnetic fluids consisting of magnetic nanoparticles (MNPs) functionalised by different amino acids (AAs): glycine (Gly), lysine (Lys) and tryptophan (Trp), and the influence of AA–MNP complexes on the MRI relaxivity. We found that the AA coating affects the size of dispersed particles and isoelectric point, as well as the zeta potential of AA–MNPs differently, depending on the AA selected. Moreover, we showed that a change in hydrodynamic diameter results in a change to the relaxivity of AA–MNP complexes. On the one hand, we observed a decrease in the relaxivity values, r₁ and r₂, with an increase in hydrodynamic diameter (the relaxivity of r₁ and r₂ were comparable with commercially available contrast agents); on the other hand, we observed an increase in r₂* value with an increase in hydrodynamic size. These findings provide an interesting preliminary look at the impact of AA coating on the relaxivity properties of AA–MNP complexes, with a specific application in molecular contrast imaging originating from magnetic nanoparticles and magnetic resonance techniques.

【 授权许可】

Unknown