Cognitive Impact of Cerebellar Non-invasive Stimulation in a Patient With Schizophrenia

Frontiers in Psychiatry

Charles Laidi¹  Dominique Januel²  Florence Durand²  Noomane Bouaziz²  Alex Suarez-Perez⁴  Carole Levenes⁴  Caroline Février⁵ 

[1] Fondation Fondamental, Créteil, France;Hôpital de Ville Evrard, Unité de Recherche Clinique, Neuilly-sur-Marne, France;Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, France;Integrative Neuroscience and Cognition Center (INCC UMR8002), Centre National de la Recherche Scientifique (CNRS), Institute for Neuroscience and Cognition, University of Paris, Paris, France;Pôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté de Médecine de Créteil, DMU IMPACT, Hôpitaux Universitaires Mondor, Créteil, France;UNIACT, Psychiatry Team, Neurospin Neuroimaging Platform, CEA Saclay, Gif-sur-Yvette, France;

关键词: schizophrenia;    tDCS—transcranial direct current stimulation;    cerebellum;    eyeblink conditioning;    cognition;   

DOI  :  10.3389/fpsyt.2020.00174

来源: DOAJ

【 摘 要 】

Cerebellum plays a role in the regulation of cognitive processes. Cerebellar alterations could explain cognitive impairments in schizophrenia. We describe the case of a 50 years old patient with schizophrenia whom underwent cerebellar transcranial direct current stimulation (tDCS). In order to study the effect of cerebellar stimulation on cognitive functions, the patient underwent a neuropsychological assessment and an eyeblink conditioning (EBC) protocol. Although the effect of brain stimulation cannot be only assessed in a single-case study, our results suggest that cerebellar stimulation may have an effect on a broad range of cognitive functions typically impaired in patients with schizophrenia, including verbal episodic, short term, and working memory. In addition to neuropsychological tests, we evaluated the cerebellar function by performing EBC before and after tDCS. Our data suggest that tDCS can improve EBC. Further clinical trials are required for better understanding of how cerebellar stimulation can modulate cognitive processes in patients with schizophrenia and healthy controls.

【 授权许可】

Unknown