Tolvaptan vs. furosemide‐based diuretic regimens in patients hospitalized for heart failure with hyponatremia (AQUA‐AHF)

ESC Heart Failure

Luanda P. Grazette¹  Michael W. Fong¹  Uri Elkayam¹  Rani Y. Upadhyay¹  Allen Kuo¹  Andrew J. Yoon¹  Anilkumar Mehra¹  Emily E. Han²  Tien M.H. Ng²  Mimi Lou² 

[1] Division of Cardiovascular Medicine University of Southern California Los Angeles CA USA;School of Pharmacy University of Southern California Los Angeles CA USA;

关键词: Vasopressin;    Diuretics;    Heart failure;    Hyponatremia;   

DOI  :  10.1002/ehf2.12783

来源: DOAJ

【 摘 要 】

Abstract Aims Hyponatremia is associated with poorer outcomes and diuretic response in patients hospitalized for heart failure. This study compared a tolvaptan‐based vs. furosemide‐based diuretic regimen on short‐term clinical responses in hyponatremic acute heart failure. Methods and results Prospective, randomized, open‐label, parallel‐group, single‐centre study comparing oral tolvaptan vs. continuous infusion furosemide. Thirty‐three subjects requiring hospitalization for acute congestive heart failure, and a serum sodium < 135 mmol/L, were randomized to tolvaptan 30 mg orally daily or furosemide 5 mg/h intravenously for initial 24 h, after which treatments could be escalated. Median daily dose throughout was tolvaptan 30 mg and furosemide 120 mg, with four subjects in each group requiring dose escalation. Urine output and net fluid balance were not different between groups at 24 h or subsequent time points up to 96 h. Changes in estimated glomerular filtration rate were comparable. Cystatin C improved at 24 h with tolvaptan compared with furosemide (−6.4 ± 11.8 vs. 4.1 ± 17.2% change, P = 0.036), but the effect was transient. No significant between group differences were seen for NT‐proBNP, plasma renin activity, or urinary neutrophil gelatinase‐associated lipocalin:Cr. Serum sodium, as well as copeptin levels, increased with tolvaptan compared with furosemide. Conclusions Oral tolvaptan was associated with similar, but not superior, diuresis compared with intravenous furosemide for acute heart failure with concomitant hyponatremia.

【 授权许可】

Unknown