Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives

Polymers

Zhanyong Guo¹  Yingqi Mi¹  Qing Li¹  Xueqi Sun¹  Jingjing Zhang¹  Xiguang Liu²  Yuan Chen² 

[1] Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China;School of Chemistry and Materials Science, Ludong University, Yantai 264025, China;

关键词: starch;    chemical modification;    1,2,3-triazole;    antioxidant activity;   

DOI  :  10.3390/polym12010112

来源: DOAJ

【 摘 要 】

In this study, starch was chemically modified to improve its antioxidant activity. Five novel cationic 1,2,3-triazole functionalized starch derivatives were synthesized by using “click” reaction and N-alkylation. A convenient method for pre-azidation of starch was developed. The structures of the derivatives were analyzed using FTIR and ¹H NMR. The radicals scavenging abilities of the derivatives against hydroxyl radicals, DPPH radicals, and superoxide radicals were tested in vitro in order to evaluate their antioxidant activity. Results revealed that all the cationic starch derivatives (2a−2e), as well as the precursor starch derivatives (1a−1e), had significantly improved antioxidant activity compared to native starch. In particular, the scavenging ability of the derivatives against superoxide radicals was extremely strong. The improved antioxidant activity benefited from the enhanced solubility and the added positive charges. The biocompatibility of the cationic derivatives was confirmed by the low hemolytic rate (<2%). The obtained derivatives in this study have great potential as antioxidant materials that can be applied in the fields of food and biomedicine.

【 授权许可】

Unknown