Annotating long intergenic non-coding RNAs under artificial selection during chicken domestication

BMC Evolutionary Biology

Ling-Qun Ye¹  Ming-Shan Wang¹  Dong-Dong Wu¹  Yun-Mei Wang¹  Ya-Ping Zhang¹  Hai-Bo Xu¹  Newton Otieno Otecko¹ 

[1]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences

关键词: Artificial selection;    Domestication;    Long intergenic non-coding RNA;    Chicken;    Population genome;    Transcriptome;   

DOI  :  10.1186/s12862-017-1036-6

来源: DOAJ

【 摘 要 】

Abstract Background Numerous biological functions of long intergenic non-coding RNAs (lincRNAs) have been identified. However, the contribution of lincRNAs to the domestication process has remained elusive. Following domestication from their wild ancestors, animals display substantial changes in many phenotypic traits. Therefore, it is possible that diverse molecular drivers play important roles in this process. Results We analyzed 821 transcriptomes in this study and annotated 4754 lincRNA genes in the chicken genome. Our population genomic analysis indicates that 419 lincRNAs potentially evolved during artificial selection related to the domestication of chicken, while a comparative transcriptomic analysis identified 68 lincRNAs that were differentially expressed under different conditions. We also found 47 lincRNAs linked to special phenotypes. Conclusions Our study provides a comprehensive view of the genome-wide landscape of lincRNAs in chicken. This will promote a better understanding of the roles of lincRNAs in domestication, and the genetic mechanisms associated with the artificial selection of domestic animals.

【 授权许可】

Unknown