Neurosarcoidosis - an ever-present clinical challenge

Srpski Arhiv za Celokupno Lekarstvo

Bubanja Dragana¹  Stojković-Lalošević Milica²  Baralić Marko³  Mihailović-Vučinić Violeta⁴  Dimić-Janjić Sanja⁴  Stjepanović Mihailo⁴  Buha Ivana⁵  Belić Slobodan⁵  Marić Nikola⁵  Stjepanović Mirjana⁶ 

[1] Clinical center of Kragujevac, Internal clinic, Kragujevac, Serbia;Clinical center of Serbia, Clinic of gastroenterology, Belgrade, Serbia;Clinical center of Serbia, Clinic of nephrology, Belgrade, Serbia;Clinical center of Serbia, Clinic of pulmonology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia;Clinical center of Serbia, Clinic of pulmonology, Belgrade, Serbia;Dr Laza Lazarević The Special Psychiatric Hospital, Belgrade, Serbia;

关键词: sarcoidosis;    neurosarcoidosis;    cerebrospinal liquid;    diagnostics;    treatment;   

DOI  :  10.2298/SARH200805012S

来源: DOAJ

【 摘 要 】

Sarcoidosis afflicts the central nervous system more frequently than previously believed. Neurological symptoms are present in roughly one-half of patients, and depend on the location in the central nervous system. The probability of spontaneous regression is significantly less when compared to other forms of sarcoidosis, which means that the proper diagnosis and treatment is paramount. Even when properly treated, functional defects are not uncommon. Majority of these patients require immunomodulating drugs and continuous follow-up. New immunomodulating drugs, especially biological agents, have shown to be significantly more effective, with fewer side effects, and are important when corticosteroids could not be applied. Less invasive methods, such as cerebrospinal analysis, help greatly in the diagnostics procedure, and require further research and improvement.

【 授权许可】

Unknown