Clinical Features and Influencing Factors for the Prognosis of Patients With Sudden Deafness

Frontiers in Neurology

Wumin Yu¹  Jian Wu²  Ying Wang³  Wei Lin⁴  Xiaoxing Xie⁴  Gaoyun Xiong⁴  Yanping Ge⁴  Kailei Yan⁵  Ze Xiang⁶ 

[1] Basic Medical College, Zhejiang Chinese Medical University, Hangzhou, China;Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China;Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China;Department of Otolaryngology, Tongde Hospital of Zhejiang Province, Hangzhou, China;The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China;Zhejiang University School of Medicine, Hangzhou, China;

关键词: clinical characteristics;    risk factors;    treatment effects;    prognosis;    sudden deafness;   

DOI  :  10.3389/fneur.2022.905069

来源: DOAJ

【 摘 要 】

BackgroundsStudies on risk factors influencing the prognosis of patients with sudden onset deafness are lacking.MethodsFrom March 2018 to March 2021, 500 patients, from the Tongde Hospital in Zhejiang Province, with sudden onset deafness were enrolled. We collected clinical information from the hospital medical records, including certain demographic characteristics, information related to sudden-onset deafness, and laboratory parameters. Univariate and multivariate analyses were performed to determine independent prognostic risk factors for patients with sudden deafness. Additionally, we also employed orthogonal partial least squares discriminant analysis (OPLS-DA) to analyze the data of these enrolled patients.ResultsThe baseline clinical characteristics of the enrolled patients were analyzed. Based on their prognoses, the included patients were divided into the overall effective and ineffective groups. Between these two groups, the univariate and multivariate analyses were performed. Age, type of hearing curve at the initial diagnosis, acute phase, and sudden deafness site were found to be independently associated with the prognoses of patients with sudden deafness (all P < 0.05). Through the OPLS-DA, the sudden deafness site was found to be an indicator with the highest predictive power.ConclusionsAge, type of hearing curve at the initial diagnosis, acute phase, and sudden deafness site were all independently correlated with the prognoses of patients with sudden deafness and, therefore, need to be emphasized.

【 授权许可】

Unknown