Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent

Frontiers in Genetics

COVID-19 Host Genetics Initiative¹  Antonella De Lillo²  Renato Polimanti³  Gita A Pathak³  Frank R Wendt³  Flavio De Angelis³ 

[1] ;Division of Human Genetics in Psychiatry, Yale School of Medicine, New Haven, CT, United States;VA CT Healthcare System, West Haven, CT, United States;

关键词: alcohol;    causal inference;    COVID-19;    diabetes;    genetic overlap;    SARS-CoV-2;   

DOI  :  10.3389/fgene.2021.765247

来源: DOAJ

【 摘 要 】

Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use (genetic causality proportion (gĉp) with severe respiratory COVID-19 = 0.576, p = 1.07 × 10−5 and hospitalized COVID-19 = 0.713, p = 0.003), and alcohol drinking status (gĉp with severe respiratory COVID-19 = 0.633, p = 7.04 × 10−5 and hospitalized COVID-19 = 0.848, p = 4.13 × 10−13). COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors and potential long-term health effects of severe response to infection.

【 授权许可】

Unknown