A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles

Nanomaterials

Yongqiang Wen¹  Yaya Cheng¹  Hongwu Du¹  Yansheng Li¹  Xueji Zhang¹  Liping Xu¹  Peixun Zhang² 

[1] Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China;Peking University People’s Hospital, Beijing 100083, China;

关键词: molecular beacon sensors;    switch;    self-assembly;    surface-enhanced Raman scattering (SERS);    gold nanoparticles;   

DOI  :  10.3390/nano6020024

来源: DOAJ

【 摘 要 】

In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS “hotspots”. This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection.

【 授权许可】

Unknown