Lipomatrix: A Novel Ascorbyl Palmitate-Based Lipid Matrix to Enhancing Enteric Absorption of Serenoa Repens Oil

International Journal of Molecular Sciences

Erik Tedesco¹  Elisa Meneghetti¹  Federico Benetti¹  ArrigoFrancesco Giuseppe Cicero²  Marzia Pellizzato³  Andrea Fratter³  Vera Mason³  Stefano Valier⁴ 

[1] ECSIN-European Center for the Sustainable Impact of Nanotechnology, ECAMRICERT SRL, I-45100 Rovigo, Italy;Faculty of Medicine and Surgery, Department of Cardiovascular Disease Prevention Research Unit, Internal Medicine and Lipidology, University Alma Mater, Bologna, Via Massarenti 9, Pavilion 2, 40138 Bologna, Italy;Nutraceutical Research and Innovation Technology Department, Labomar Research, Via Fabio Filzi, 55, 31036 Istrana (TV), Italy;PHF SA, 6900 Lugano, Switzerland;

关键词: ascorbyl palmitate;    mono and diglycerides of fatty acids;    natural lipophilic compounds;    nutraceutical products;    Serenoa repens oil;    enteric bioaccessibility;   

DOI  :  10.3390/ijms20030669

来源: DOAJ

【 摘 要 】

The class of lipophilic compounds coming from vegetal source represents a perspective in the adjuvant treatment of several human diseases, despite their poor bioavailability in humans. These compounds are generally soluble in fats and poorly soluble in water. The major reason for the poor bioavailability of lipophilic natural compounds after oral uptake in humans is related to their reduced solubility in enteric water-based fluids, leading to an ineffective contact with absorbing epithelium. The main goal to ensure efficacy of such compounds is then creating technological conditions to deliver them into the first enteric tract as hydro-dispersible forms to maximize epithelial absorption. The present work describes and characterizes a new technological matrix (Lipomatrix, Labomar Research, Istrana, TV, Italy) based on a molten fats core in which Ascorbyl Palmitate is embedded, able to deliver lipophilic compounds in a well-dispersed and emulsified form once exposed to duodenal fluids. Authors describe and quantify Lipomatrix delivery of Serenoa repens oil through an innovative in vitro model of human gastro-enteric digestion, reporting results of its improved bioaccessibility, enteric absorption and efficacy compared with not formulated Serenoa repens oil-containing commercial products using in vitro models of human intestine and prostatic tissue.

【 授权许可】

Unknown